New Articles

Antisense Correction of SMN2 Splicing in the CNS Rescues Necrosis in a Type III SMA Mouse Model

Hua Y, Sahashi K, Hung G, Rigo F, Passini MA, Bennett CF, Krainer AR

Genes Dev. 2010 Jul 12. [Epub ahead of print]

Peptide Nucleic Acids Conjugated to Short Basic Peptides Show Improved Pharmacokinetics and Antisense Activity in Adipose Tissue

Wancewicz EV, Maier MA, Siwkowski AM, Albertshofer K, Winger TM, Berdeja A, Gaus H, Vickers TA, Bennett CF, Monia BP, Griffey RH, Nulf CJ, Hu J, Corey DR, Swayze EE, Kinberger GA

J Med Chem. 2010 May 27;53(10):3919-26

Effect of Apolipoprotein-B Synthesis Inhibition on Liver Triglyceride Content in Patients With Familial Hypercholesterolemia

Visser ME, Akdim F, Tribble DL, Nederveen AJ, Kwoh TJ, Kastelein JJ, Trip MD, Stroes ES

J Lipid Res. 2010 May;51(5):877-8

Matrix Metalloproteinase (MMP)-13 Regulates Mammary Tumor-Induced Osteolysis by Activating MMP9 and Transforming Growth Factor-{beta} Signaling at the Tumor-Bone Interface

Nannuru KC, Futakuchi M, Varney ML, Vincent TM, Marcusson EG, Singh RK

Cancer Res. 2010 Apr 20. [Epub ahead of print]

Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy

Akdim F, Stroes ES, Sijbrands EJ, Tribble DL, Trip MD, Jukema JW, Flaim JD, Su J, Yu R, Baker BF, Wedel MK, Kastelein JJ

J Am Coll Cardiol. 2010 Apr 13;55(15):1611-8

Mipomersen, an Apolipoprotein B Synthesis Inhibitor, for Lowering of LDL Cholesterol Concentrations in Patients With Homozygous Familial Hypercholesterolaemia: a Randomised, Double-Blind, Placebo-Controlled Trial

Raal FJ, Santos RD, Blom DJ, Marais AD, Charng MJ, Cromwell WC, Lachmann RH, Gaudet D, Tan JL, Chasan-Taber S, Tribble DL, Flaim JD, Crooke ST

Lancet. 2010 Mar 20;375(9719):959-61

Silencing glycogen synthase kinase-3{beta} inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1

Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N

J Biol Chem. 2010 March 12;285(11):8244-55

Antisense Oligonucleotide Targeting of Insulin-Like Growth Factor-1 Receptor (IGF-1R) in Prostate Cancer

Furukawa J, Wraight CJ, Freier SM, Peralta E, Atley LM, Monia BP, Gleave ME, Cox ME

Prostate. 2010 Feb 1;70(2):206-18

Synthesis and Biophysical Evaluation of 2',4'-Constrained 2'O-Methoxyethyl and 2',4'-Constrained 2'O-Ethyl Nucleic Acid Analogues

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE

J Org Chem. 2010 Feb 8. [Epub ahead of print]

Antisense Oligonucleotides Containing Conformationally Constrained 2',4'-(N-Methoxy)aminomethylene and 2',4'-Aminooxymethylene and 2'-O,4'-C-Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

Prakash TP, Siwkowski A, Allerson CR, Migawa MT, Lee S, Gaus HJ, Black C, Seth PP, Swayze EE, Bhat B

J Med Chem. 2010 Jan 28;53:1636–1650

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

Carter BZ, Mak DH, Schober WD, Koller E, Pinilla C, Vassilev LT, Reed JC, Andreeff M

Blood. 2010 Jan 14;115(2):306-14. Epub 2009 Nov 6.

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

Bennett CF, Swayze EE

Annu Rev Pharmacol Toxicol. 2010;50:259-93

Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI

Cell Metab. 2009 Dec;10(6):499-506

Activity of siRNAs with 2-Thio-2'-O-Methyluridine Modification in Mammalian Cells

Prakash TP, Naik N, Sioufi N, Bhat B, Swayze EE

Nucleosides, Nucleotides and Nucleic Acids. 2009 Oct 10;28:902-910

Binding and Cleavage Specificities of Human Argonaute2

Lima WF, Wu H, Nichols JG, Sun H, Murray HM, Crooke ST

J Biol Chem. 2009 Sep 18;284(38):26017-28.

Off-target and a Portion of Target-specific siRNA Mediated mRNA Degradation is Ago2 'Slicer' Independent and Can be Mediated by Ago1

Vickers TA, Lima WF, Wu H, Nichols JG, Linsley PS, Crooke ST

Nucleic Acids Research, doi:10.1093/nar/gkp735

Phase I Study of the c-raf-1 Antisense Oligonucleotide ISIS 5132 in Combination with Carboplatin and Paclitaxel in Patients with Previously Untreated, Advanced Non-Small Cell Lung Cancer

Fidias P, Pennell NA, Boral AL, Shapiro GI, Skarin AT, Eder JP Jr, Kwoh TJ, Geary RS, Johnson BE, Lynch TJ, Supko JG

J Thorac Oncol. 2009 Sep;4(9):1156-62

Specific Role for Acyl-CoA:Diacylglycerol acyltransferase 1 (Dgat1) in Hepatic Steatosis Due to Exogenous Fatty Acids

Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV Jr.

Hepatology. 2009 Aug:50(2):434-42

Effect of Dose and Plasma Concentration on Liver Uptake and Pharmacologic Activity of a 2'-Methoxyethyl Modified Chimeric Antisense Oligonucleotide Targeting PTEN.

Geary RS, Wancewicz E, Matson J, Pearce M, Siwkowski A, Swayze E, Bennett F

Biochem Pharmacol. 2009 Aug;78(3):284-91.

Enhanced Expression and Shedding of Receptor Activator of NF-kappaB Ligand During Tumor-bone Interaction Potentiates Mammary Tumor-induced Osteolysis

Nannuru KC, Futakuchi M, Sadanandam A, Wilson TJ, Varney ML, Myers KJ, Li X, Marcusson EG, Singh RK

Clin Exp Metastasis. 2009 Jul 10;26(7):797-808

SirT1 Knockdown in Liver Decreases Basal Hepatic Glucose Production and Increases Hepatic Insulin Responsiveness in Diabetic Rats

Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11288-93.